Mary was born on January 2, 1969 to Louis Vasquez, a wealthy oil businessman, and Viola Vasquez (née Sabino), an Italian-American socialite in Royal Woods. The Vasquez family are very wealthy and own an international corporation called the Vasquez Oil Corporation, they descend from oil magnate Fernando Vasquez, who immigrated to the United States in 1912. Mary was soon baptized at St. Paul's Cathedral. She is a childhood friend of future U.S. Senator Lucas Loud and future Royal Woods Mayor William Loud Jr. She studied in Harvard and earned a PhD in 1996, and became a doctor.